Therapeutic cream for dermatitis

ABSTRACT

An innovative therapy of various dermatitis such as atopic dermatitis can be attained by antibacterial, antiviral, antiallergic, antiphlogistic, blood-circulation accelerating, antifungal, sterilizing, anti-itching actions by the above respective ingredients, accelerating action for permeation of pharmacologically active ingredients to deep region of skin by Cnidii Rhizoma and Japanese Angelicae Root, accelerating action for keratinization in the diseased part by salicylic acid and resorcinol.

TECHNICAL FIELD

The present invention relates to a cream for therapy of dermatitis, andrelates to a cream for therapy of dermatitis, including eczema, which issuitable to treat various dermatitis, particularly, for example, atopicdermatitis, and in which extracts drawn from plants are used.

BACKGROUND ART

Patients having dermatitis, particularly patients having atopicdermatitis, have suddenly increased in recent years. While the groundsfor the sudden increase of patients having atomic dermatitis has yet notbeen sufficiently clarified, it as considered that the grounds areclassified into three large groups. The first ground is a change in theeating habit. That is, by an increase in consumption of flesh and meatas well as dairy product such as butter, cheese and the like, changedfrom the conventional vegetable-centered diet, it is considered that thephysical constitution itself has been changed. The second ground is achange in the living environment. That is, by a change from theconventional houses using wood, plaster, paper, rush-mat and the like tohouses using various synthetic building materials, chemicallysynthesized size, chemical mat and the like, it is considered thatvarious chemical substances contained in these building materials arereleased in the living environment resulting in the change in thephysical constitution. In addition, irritation on the skin may beincreased by a change from the conventional clothes made of naturalmaterial fibers such as wool, cotton and the like to clothes made ofvarious chemical fibers resulting in increase of irritation onto theskin, and a change from washing with soaps to washing with syntheticdetergents and dry-cleaning, and a use of shampoos, rinses, hairconditioners may also be grounds. As the third ground, it is consideredthat a level down in immunity is caused by speed-up in the living rhythmand raised level of work proceeded in all the aspect, resulting inexposure of infants and adults to excess stresses.

Atopic dermatitis is a disease occurred a from two- or three-months oldto about ten years old when resistance power is poor and is known to bea disease accompanied by intense itch with wetting and erosion; the itchis characterized in that it gives a mental pain to the patients andaggravates symptoms by scratching; particularly, in the case of infantpatients, it is painful not only for the patients themselves but alsofor parents and near relations.

Although various countermeasures nave been examined and practiced forthe prophylaxis or therapy of this atopic dermatitis, most of them arecountermeasures belonging to the symptomatic therapy; particularly knoware antihistaminic agents, antiallergic agents, antiphologistic agents,steroidal agents and the like for the symptomatic therapy of westernmedicine, but all of them have been unsatisfactory in pharmcologicaleffect and side effects.

For example, although antihistaminic agents and antiallergic agents havean action of suppressing itch, they have problems in the duration ofeffect and antiphologistic effect, and are problematic in long-termadministration for chronic itching because sometimes they bring abouttroubles in the daily life due to symptoms such as weariness, sleepinessand the like caused by administration.

Although steroidal agents have generally a high pharmacological effect,they are fundamentally drugs for suppressing symptoms, and sometimes thecure cannot be attained even by a long-term administration of steroidalagents; they are problematic because of their strong drug-characteristicside effects; for example, sometimes they cause dermatrophia in whichthe skin becomes thin like a flimsy, capillarectasia in which capillaryblood vessel in the skin rises forming red-skin, and various infectionssuch as fungal injection, folliculitis (pimple), herpes and the like dueto decrease in the immune power. Additionally, when a very large amountof a very strong steroidal agent is used within a short period,sometimes functional disorder of adrenal grand, shock and the likeoccurs. In another case, when use of steroidal agent is suddenlydiscontinued after a long-term use, problems arises that the daily lifebecome difficult by a revival of symptoms suppressed before by thesteroidal agent and a rebound phenomenon (jump back) in which symptomssuch as itching, redness, swelling and the like increases more thanbefore.

In addition, based on the fact that staphylococcus aureus and otherswere found in the diseased part of atopic dermatitis, application ofIsodine, a disinfectant agent, has been practiced in some cases. Indeedthe effect of application of Isodine has been confirmed in a skin onwhich bacteria is abundant, Isodine is effective only to bacteriafloating on the surface of skin, and has no effect against bacteriawithin a biological membrane or bacteria invaded deeply in the skin. Notonly that, Isodine is liable to cause a rash, and when once a rash iscaused, the reaction is repeated and sometimes an ulcer is formed on theskin or a reaction such as shock or the like is caused. Moreover,sometimes hypothyroidism is induced.

From a similar viewpoint against bacteria, sometimes super acidic wateris used, but problems similar to those in Isodine arise.

In addition to the above-described countermeasures based on westernmedicine, treatments by Sino-Japanese medicament have also beenpracticed. For example, respective crude drug ingredients of Rhizomacoptidis detoxication soup and Heat-clearing and wind-dispelling poweras therapeutic agents for atopic dermatitis are Baikal skullcap, CoptisRoot, Gardenia Fruit, Amur Cork Tree and Japanese Angelicae Root,Chinese Fox-Glove Root, Gypsum, Saposhnikoviae Radix, Great BurdockAchene, Akebiae Stem, Anemarrhena Rhizome, Sesame, Cryptotympana atrata,Lightyellow Sophora Root; since they belong to anti-itching agents forsuppressing itch or blood-activation agents for stopping pain byimproving blood circulation and therefore respective drugs belong to thesymptomatic therapy dealing with individual symptoms, these medicamentscannot be said to be medicaments for fundamental cure.

In addition, although drugs for paint such as ointments containingSino-Japanese drugs have been prepared, these belong also to so-calledsymptomatic therapy and therefore are far from the fundamental cure byimprovement of physical constitution.

Moreover, while the activity is mild, Sino-Japanese drugs forsuppressing the aforementioned side effects have been proposed. Forexample, Japanese Patent Publication JP-A-6-166629 has proposed an agentfor improving atopic dermatitis formed by mixing Potent BupleuriDecoction and Angelica peony powder. Indeed side effects are suppressedin these agents for improving atopic dermatitis, there is a problem thatits anti-itching effect and so on are not sufficient.

Beside, Japanese Patent Publication JP-A-8-301779 has proposed anexternal drug for atopic dermatitis containing as an active ingredientan extract solution from one, two or more plants selected from the groupconsisting of Linden, Lemonbalm, Fenugreek, Borage, Lingusticumchuanxiong Hort, Pink Pyrola, Willowleaf Swallowwort Rhizome,Clerodendron cyrtophyllum, and Clinopodium chinense.

However, while the ointment for atopic dermatitis exerts someanti-itching effect and disease-improving effect by applying it onto thediseased part, there has been a problem that a sufficient effect was notobtained.

Therefore, the purpose of the present invention is to provide a creamfor therapy of dermatitis which can treat atopic dermatitis or the like.

DISCLOSURE OF THE INVENTION

The cream for therapy of dermatitis according to the present inventionis characterized in that it contains extracts drawn from one, two ormore plants selected from the group consisting of Light yellow SophoraRoot, Turmeric, Magnolia Bark, Moutan Bark, Isatis Leaf, and BorneoCamphor Tree (Dryobalanops aromatica Gaertn. f.) (claim 1).

The families, main components and principal activities of the plants asraw materials for the above-mentioned respective extracts drawn fromplants are described in the following:

(1) Lightyellow Sophora Root (Kujin) (Sophora flavescens Ait.)

Plant family: Leguminosae plant fravescens

Main components: Matorine, Kurarinore

Principal activities: Antibacterial, Antiviral, Antiallergic

(2) Turmeric (Ukon) (Curcuma aromatica Salisb.)

Plant family: Zingiberacea Plant

Main components: Curcumol, Curdion

Principal activities: Antibacterial, Antiphlogistic, Blood-circulationimproving

(3) Magnolia Bark (Kouboku) (Magnolia officinalis Rehd. et Wils.)

Plant family: Magnoliaceae plant

Main components: Honoriol, β-eudesml

Principal activities: Antibacterial, Antiphlogistic

(4) Moutan Bark (botanpi) (Paeonia suffruticosa Andr.)

Plant family: Paeoniaceae plant

Main components: Paeonol, Bennzoic acid, Phytosterol

Principal activities: Antiphlogistic, Blood-circulation improving

(5) Isatis Leaf (Taiseiyou) (Isatis tinctoria L.)

Plant family: Acantaceae plant

Main components: Indigo, Indirubin, Idican, Trace Element

Principal activities: Antibacterial, Antiviral, Antiallergic

In addition, Isatis Leafs prepared from Baphicacanthus cusia Bremek,Isatis indigotica Fort, Polygonum tinctorium Ait., Clerodendroncyrtophyllum Turcz. and the like can be used.

(6) Borneo Camphor Tree (Hyouhen) (Dryobalanops aromatica Gaertn. f.)

Plant Family: Diptercarpaceas plant. Crystals prepared by processingresin from Dipterocarpus retusus.

Main components: Volatile oil, α-Borneol

Principal activities: Antibacterial, Antiphiogistic, Anti-itching

According to the above described cream for therapy of dermatitis, curingpotential is elevated by antibacterial effect of Light yellow SophoraRoot, Turmeric, Magnolia Bark, Isatis Leaf, and Borneo Camphor Tree(Dryobalanops aromatica Gaertn. f.), antiviral and antiallergic effectsof Light yellow Sophora Root and Isatis Leaf, antiphlogistic effect ofTurmeric, Magnolia Bark, Moutan Bark and Borneo Camphor Tree(Dryobalanops aromatica Gaertn. f.), blood-circulation improving effectof Turmeric and Moutan Bark, anti-itching effect of Borneo Camphor Tree(Dryobalanops aromatica Gaertn. f.), or by a synergistic effect of them,and also by a depression effect against allergens, and thus variousdermatitis including atopic dermatitis can be treated.

The invention is also characterized in that an auxiliary agent is addedto the above described extracts drawn from plants (claim 2).

As the auxiliary agent, materials having various auxiliary activitiescan be adopted, including one for assistance and enhancement ofpharmacological effects, namely antibacterial, antiviral, antiallergic,antiphlogistic, blood-circulation and anti-itching effects, ofaformentioned extracts drawn from plants, one for addition ofpharmacological effects, for example, antifungal, sterilizing effectsand others, which are lacking in aforementioned extracts drawn fromplants, one for improvement of easiness of applying as a cream in theform of an ointment by dissolving the aforementioned extracts drawn fromplants, one for accelerating skin permeation so that thepharmacologically active ingredients applied onto the diseased partpermeate deeply into inside of the skin, or further, one foraccelerating keratinization of skin by the therapeutic effects of thepharmacologically active ingredients applied onto the diseased part, andso on.

According to the above cream for therapy of dermatitis, with theauxiliary agent, the therapeutic effect is promoted by assisting orenhancing the pharmacological effects of the extracts drawn from plantsnamely Lightyellow Sophora Root, Turmeric, Magnolia Bark, Moutan Bark,Isatis Leaf, and Borneo Camphor Tree (Dryobalanops aromatica Gaertn.f.), by adding a pharmacological effect lacking in the above describedextracts drawn from plants, or by improving easiness of applying as acream, or further, or by accelerating effect of skin permeation andacceleration effect of keratinization, and inconvenience such as sideeffects occurred by use continued for a period needed in therapy and thelike can be avoided.

The invention is also characterized in that the auxiliary agent includesan auxiliary extract drawn from a plant, accelerator for skinpermeation, accelerator for keratinization, mutton oil, alcohol andwhite soft paraffin (claim 3).

According to the above cream for therapy of dermatitis, with theauxiliary extract drawn from a medicinal herb, the pharmacologicaleffects of the extracts drawn from plants namely Lightyellow SophoraRoot, Turmeric, Magnolia Bark, Moutan Bark, Isatis Leaf, and BorneoCamphor Tree (Dryobalanops aromatica Gaertn. f.) can be assisted orenhanced, and the therapeutic effect can be promoted by adding apharmacological effect as described above lacking in the above describedextracts drawn from plants, by improving easiness of applying as acream, or by accelerating agent for skin permeation acting forpermeation of the pharmacologically active ingredients deeply under theskin of diseased part, and by accelerating agent for keratinization ofskin acting for keratinization of the diseased part so that themetabolism in the diseased part is elevated.

Besides, mutton oil (purified lanolin) acts for adjustment of viscosityin the cream for therapy of dermatitis and is useful for holding of thepharmacologically active ingredients on the diseased part afterevaporation of alcohol and water described below, alcohol acts foreasiness of dissolving respective ingredients and is useful forimparting cold feeling on applying, and white soft paraffin is usefulfor easiness of applying onto the diseased part by keeping viscosity asa cream.

The invention is also characterized in that the above describedauxiliary extract drawn from a plant contains extracts drawn from one,two or more selected from the group of Baikal Skullcap, Amur Cork Tree,Angelicae Dahuricae Root, Lemon, Smartweed and Licorice (claim 4).

The families, main components and principal activities of the abovedescribed auxiliary agent are described in the following:

(1) Baikal Skullcap (Ougon) (Scutellaria baikcalensis Georgi.)

Plant family: Labiatae Plant

Main component: Baicalin, Baicalein

Principal activity: Antibacterial, Antiviral, Antiallergic

(2) Amur Cork Tree (Oubaku) (Phellodendron amurense Rupr.)

Plant family: Rutaceae plant

Main components: Berberine, Phellodencorine

Principal activity: Antibacterial, Antiphlogistic

(3) Angelicae Dahuricae Root (Hakusi) (Angelica dahurica Benth. etHook.)

Plant family: Umbelliferae plant

Main components: Byak-anngelicin, Imperstorin

Principal activities: Antibacterial, Antiphiogistic, Antiallergic

(4) Lemon (Lemon)

Plant family: Rutaceae plant, Food Additive

Main component: Lemon acid

Principal activities: Antiallergic

(5) Smartweed (Kojou) (Polygonum csupidatum Sieb. et Zucc.)

Plant family: Polygonaceae plant (Smartweed Plant)

Main components: Glycosides, Flabonoids

Principal activities: Antibacterial, Antiviral, Antiallergic

(6) Licorice (Kanzou) (Glycyrrhiza uralensis Fisch.)

Plant family: Legminosae plant

Main components: Glycyrrheti acid, Flabonoids

Principal activities: Antiallergic, Antiphlogistic

According to the above cream for therapy of dermatitis, with the effectsof respective auxiliary agents, the pharmacological effects, namelyantibacterial, antiviral, antiallergic, antiphlogistic,blood-circulation improving, anti-itching effects and the like, ofextracts drawn from plants consisting of Lightyellow Sophora Root,Turmeric, Magnolia Bark, Moutan Bark, Isatis Leaf and Borneo CamphorTree (Dryobalanops aromatica Gaertn. f.) can be reinforced byantibacterial activity of Baikal Skullcap, Amur Cork Tree, AngelicaeDahuricae Root and Smartweed, antiviral activity of Baikal Skullcap andSmartweed, antiallergic activity of Baikal Skullcap, Angelicae DahuricaeRoot, Lemon, Smartweed and Licorice and antiphlogistic activity of AmurCork Tree, Angelicae Dahuricae Root and Licorice, resulting in a creamhaving a higher therapeutic effect.

The invention is also characterized in that the above describedaccelerating agent for skin permeation contains one, two or moreselected from the group of Cnidii Rhizoma, Japanese Angelicae Root anddimethylsulfoxide (claim 5).

The families, main components and principal activities of Cnidii Rhizomaand Japanese Angelicae Root, and properties and principal activities ofdimethylsulfoxide are described in the following:

(1) Cnidii Rhizoma (Senkyu) (Ligusticum chuanxiong Hort)

Plant family: Umbelliferae plant

Main components: Volatile oil, Tetramethylpyrazine, Senkyunolide,Ferulic acid

Principal activities: Skin permeation accelerating, Blood-circulationaccelerating, Sedative, Antispasmodic

(2) Japanese Angelicae Root (Touki) (Angelic sinensis (Olive) Diels.)

Plant family: Umbelliferae plant

Main components: Volatile oil, Ferulic acid, Vitamin E, Vitamin A,Vitamin B₁₂

Principal activities: Skin permeation accelerating, Blood-circulationaccelerating, Anemia improving, Immunity regulating, Antiallergic

(3) Dimethyl sulfoxide

Properties: Soluble in alcohol and water

Principal activity: Skin permeation accelerating

According to the above cream for therapy of dermatitis, the therapeuticeffect can be elevated not only at the surface of skin but also in deeptissue of skin by permeating and penetrating effectively and deeply thepharmacologically active ingredients of the extracts drawn from plantsinto the subcutaneous tissue by the skin permeation accelerating actionof Cnidii Rhizoma, Japanese Angeleicae Root and dimethylsulfoxide, andmoreover, the therapeutic effect can be elevated by blood-circulationaccelerating, sedative and antispasmodic action of Cnidii Rhizoma, aswell as blood-circulation accelerating, anemia improving, immunityregulating and antiallergic action of Japanese Angelicae Root.

The invention is also characterized in that the above describedaccelerating agent for keratinization contains one or two selected fromthe group of salicyclic acid and resorcinol (claim 6).

The properties and principal activities of salicyclic acid andresorsinol are described briefly in the following:

(1) Salicyclic Acid (Acidum Salicylicum)

Properties: Easily soluble in alcohol, soluble in water

Principal activities: Keratinization accelerating, Antiseptic

(2) Resorcinol

Properties: Soluble in alcohol and water

Principal activities: Keratinization accelerating, Antiseptic,Antipruritic, Antimold

According to the above described cream for therapy of dermatitis, thetherapeutic effect can be increased by accelerating keratinization ofalready cured old tissue bv keratinization accelerating action ofsalicylic acid and/or resorcinol resulting in dropping out from thediseased part thereby rising new tissue up to the skin surface, togetherwith a therapeutic effect given by the therapeutically activeingredients in the extracts drawn from plants and auxiliary agents ontothe diseased part.

The invention is also characterized in that the volume ratios of theabove described auxiliary extracts drawn from plants: accelerating agentfor skin permeation: accelerating agent for keratinization are 53 to89%: 8 to 38%: 6 to 10% (claim 7).

When the extracts drawn from plants is less than 53%, appearance ofmedical effect is slow or no improving effect appears; when it exceeds89%, there is a fear that a side effect in which skin become red andswelled or the symptom become worse occurs. When accelerating agent forskin permeation is less than 8%, appearance of medical effect is slow orno improving effect appears; when it exceeds 10%, there is a fear that aside effect in which skin become red and swelled or the symptom becomeworse occurs. When accelerating agent for keratinization is less than7%, appearance of medical effect is slow or no improving effect appears;when it exceeds 10%, there is a fear that a side effect in which skinbecome red and swelled or the symptom become worse occurs.

According to the above described cream for therapy of dermatitis, therespective auxiliary agents are contained with a good balance, not onlythe therapy of surface layer in the diseased part obtainable by a highpharmacological effects and permeation effect of the pharmacologicallyactive ingredients into a deep subcutaneous tissue by the skinpermeation accelerating agent, but also a high therapeutic effects ofdermatitis is obtainable by a therapeutic action from the deepsubcutaneous tissue and accelerating effect for keratinization ofalready cured old tissue by keratinization accelerating agent, and acream having a suppressed excess irritation by applying can be obtained.

The invention is also characterized in that the volume ratios ofrespective ingredients are Lighyellow Sophora Root, 2.7 to 3.3%;Turmeric, 1.8 to 2.2%; Magnolia Bark, 1.8 to 2.2%; Moutan Bark, 1.8 to2.2%; Isatis Leaf, 0.9 to 1.1%; Borneo Camphor Tree (Dryobalanopsaromatica Gaertn. f.), 0.9 to 1.1%; Baikal Skullcap, 1.8 to 2.2%; AmurCork Tree, 1.8 to 2.2%; Angelicae Dahuricae Root, 0.9 to 1.1%; Lemon, 0to 3%; Smartweed, 0 to 1.1%; Licorice, 0 to 0.55%; Cnidii Rhizoma, 0.45to 1.1%; Japanese Angelica Root, 0 to 0.55%; salicyclic acid, 0.45 to0.55%; resorcinol, 0.45 to 0.55%; mutton oil, 2.7 to 3.3%; alcohol, 2.7to 3.3%; and white soft paraffin, 63 to 78% (claim 8).

When respective ingredients other than mutton oil, alcohol and whitesoft paraffin among the above described ingredients are less than thelower limit of the above range, appearance of medical effect is slow orno medical effect appears; when it exceeds the upper limit of the aboverange, there is a fear that a side effect in which skin become red andswelled or the symptom become worse occurs.

According to the above described cream for therapy of dermatitis, a hightherapeutic effect against atopic dermatitis can be obtained owing tothe fact that well-balanced antibacterial, antiviral, antiallergic,antiphlogistic, blood-circulation accelerating and anti-itching effectsof Lightyellow Sophora Root, Turmeric, Magnolia Bark, Moutan Bark,Isatis Leaf and Borneo Camphor Tree (Dryobalanops aromatica Gaertn. f.)as the main extracts drawn from plants, assisting action and enhancingaction for pharmacological activities by Baikal Skullcap, Amur CorkTree, Angelicae Dahuricae Root, Lemon, Smartweed, Licorice and the likeas the auxiliary extracts drawn from plants, skin permeationaccelerating action of Cnidii Rhizoma and/or Japanese Angelicae Root,and keratinization accelerating action of salicylic acid and/orresorcinol are obtained.

The invention is also characterized in that the volume ratios ofrespective ingredients are Lightyellow Sophora Root, 3%; Turmeric, 2%;Magnolia Bark, 2%; Moutan Bark, 2%; Isatis Leaf, 1%; Borneo Camphor Tree(Dryobalanops aromatica Gaertn. f.), 1%; Baikal Skullcap, 2%; Amur CorkTree, 2%; Angelicae Dahuricae Root, 1%; Lemon, 3%; Smartweed, 1%;Licorice, 0.5%; Cnidii Rhizoma, 0.5%; Japanese Angelica Root, 0.5%;salicylic acid, 0.5%; resorcinol, 0.5%; mutton oil, 3%; alcohol, 3%; andwhite soft paraffin, 70.5% (claim 9).

According to the above described cream for therapy of dermatitis, thehighest therapeutic effect against atopic dermatitis can be obtainedowing to the fact that very well-balanced antibacterial, antiviral,antiallergic, antiphlogistic, blood-circulation accelerating andanti-itching effects of lightyellow Sophora Root, Turmeric, MagnoliaBark, Moutan Bark, Isatis Leaf and Borneo Camphor Tree (Dryobalanopsaromatica Gaertn. f.) as the main extracts drawn from plants, assistingaction and enhancing action for pharmacological activities by BaikalSkullcap, Amur Cork Tree, Angelicae Dahuricae Root, Lemon, Smartweed,Licorice and the like as the auxiliary extracts drawn from plants, skinpermeating action of Cnidii Rhizoma and/or Japanese Angelicae Root, andkeratinization accelerating action of salicylic acid and/or resorcinolare obtained.

The invention is also characterized in that the volume ratios ofrespective ingredients are Lightyellow Sophora Root, 2.7 to 3.3%;Turmeric, 1.8 to 2.2%; Magnolia Bark, 1.8 to 2.2%; Moutan Bark, 1.8 to2.2%; Isatis Leaf, 0.9 to 1.1%; Borneo Camphor Tree (Dryobalanopsaromatica Gaertn. f.), 0.9 to 1.1%; Baikal Skullcap, 1.8 to 2.2%; AmurCork Tree, 1.8 to 2.2%; Angelicae Dahuricae Root, 0.9 to 1.1%; Lemon, 0to 3%; Smartweed, 0 to 1.1%; Licorice, 0 to 0.55%; dimethylsulfoxide,4.5 to 5.5%; salicylic acid, 0.45 to 0.55%; resorcinol, 0.45 to 0.55%;mutton oil, 2.7 to 3.3%; alcohol, 2.7 to 3.3%; and white soft paraffin,60 to 73% (claim 10).

According to the above described cream for therapy of dermatitis, a hightherapeutic effect against atopic dermatitis can be obtained owing tothe fact that well-balanced antibacterial, antiviral, antiallergic,antiphlogistic, blood-circulation accelerating and anti-itching effectsof Lightyellow Sophora Root, Turmeric, Magnolia Bark, Moutan Bark,Isatis Leaf and Borneo Camphor Tree (Dryobalanops aromatica Gaertn. f.)as the main extracts drawn from plants, assisting action and enhancingaction for pharmacological activities by Amur Cork Tree, AngelicaeDahuricae Root, Lemon, Smartweed, Licorice and the like as the auxiliaryextracts drawn from plants, skin permeation accelerating action ofdimethylsulfoxide, and keratinization accelerating action of salicyclicacid and/or resorcinol are obtained.

The invention is also characterized in that the volume ratios ofrespective ingredients are Lightyellow Sophora Root, 3%; Turmeric, 2%;Magnolia Bark, 2%; Moutan Bark, 2%; Isatis Leaf, 1%; Borneo Camphor Tree(Dryobalanops aromatica Gaertn. f.), 1%; Baikal Skullcap, 2%; Amur CorkTree, 2%; Angelicae Dahuricae Root, 1%; Lemon, 3%; Smartweed, 1%;Licorice, 0.5%; dimethylsulfoxide, 5%; salicylic acid, 0.5%; resorcinol,0.5%; mutton oil, 3%; alcohol, 3%; and white soft paraffin, 66.5% (claim11).

According to the above described cream for therapy of dermatitis, thehighest therapeutic effect against atopic dermatitis can be obtainedowing to the fact that very well-balanced antibacterial, antiviralantiallergic, antiphlogistic, blood-circulation accelerating andanti-itching effects of Lightyellow Sophora Root, Turmeric, MagnoliaBark, Moutan Bark, Isatis Leaf and Borneo Camphor Tree (Dryobalanopsaromatica Gaertn. f.) as the main extracts drawn from plants, assistingaction and enhancing action for pharmacological activities by Amur CorkTree, Angelicae Dahuricae Root, Lemon, Smartweed, Licorice and the likeas the auxiliary extracts drawn from plants, skin permeationaccelerating action of dimethylsulfoxide, and keratinizationaccelerating action of salicylic acid and/or resorcinol are obtained.

BRIF DESCRIPTION OF DRAWINGS

FIG. 1 (A) is a photograph showing the hollow of right hand when thepatient in CASE 1 relating to the cream according to the invention hasvisited a doctor for initial consultation.

(B) is a photograph showing the hollow of right hand after treatment.

FIG. 2 (A) is a photograph showing the sole of left foot when thepatient in CASE 1 relating to the cream according to the invention hasvisited a doctor for initial consultation.

(B) is a photograph showing the sole of left foot after treatment

FIG. 3 (A) is a photograph showing the lower abdominal region when thepatient in CASE 2 relating to the cream according to the invention hasvisited a doctor for initial consultation.

(B) is a photograph showing the lower abdominal region after treatment.

FIG. 4 (A) is a photograph showing the face when the patient in CASE 3relating to the cream according to the invention has visited a doctorfor initial consultation.

(B) is a photograph showing the face after treatment.

FIG. 5 (A) is a photograph showing the face when the patient in CASE 4relating to the cream according to the invention has visited a doctorfor initial consultation.

(B) is a photograph showing the face after treatment.

FIG. 6 (A) is a photograph showing the backside of right hand when thepatient in CASE 4 relating to the cream according to the invention hasvisited a doctor for initial consultation.

(B) is a photograph showing the backside of riaht hand after treatment.

FIG. 7 (A) is a photograph showing the face when the patient wen CASE 5relating to the cream according to the invention has visited a doctorfor initial consultation.

(B) is a photograph showing the face after treatment.

FIG. 8 (A) is a photograph showing the fingers of right hand when thepatient in CASE 6 relating to the cream according to the invention hasvisited a doctor for initial consultation.

(B) is a photograph showing the fingers of right hand after treatment.

FIG. 9 (A) is a photograph showing the sole of right foot when thepatient in CASE 7 relating to the cream according to the invention hasvisited a doctor for initial consultation.

(B) is a diagram showing the sole of right foot after treatment.

FIG. 10 (A) is a photograph showing the face when the patient in CASE 8relating to the cream according to the invention has visited a doctorfor initial consultation.

(B) is a photograph showing the face after treatment.

BEST MODE FOR CARRYING OUT THE INVENTION

The respective ingredients and weight ratios in the cream for therapy ofdermatitis (atopic cream) A: Lightyellow Sophora Root, 3%; Turmeric, 2%;Magnolia Bark, 2%; Moutan Bark, 2%; Isatis Leaf, 1%; Borneo Camphor Tree(Dryobalanops aromatica Gaertn. f.), 1%; Baikal Skullcap, 2%; Amur CorkTree, 2%; Angelicea Dahuricae Root, 1%; Lemon, 3%; Smartweed, 2%;Licorice, 0.5%; Cnidii Rhizoma, 0.5%; Japanese Angelica Root, 0.5%;salicyclic acid, 0.5%; resorcinol, 0.5%; mutton oil, 3%, alcohol, 3%;white soft paraffin, 70.5%.

The respective ingredients and weight ratios in the cream for therapy ofdermatitis (atopic cream) B: Lightyellow Sophora Root, 3%; Turmeric, 2%;Magnolia Bark, 2%; Moutan Bark, 2%; Isatis Leaf, 1%; Borneo Camphor Tree(Dryobalanops aromatica Gaertn. f.), 1%; Baikal Skullcap, 2%; Amur CorkTree, 2%; Angelicae Dahuricae Root, 1%; Lemon, 3%; Smartweed, 1%;Licorice, 0.5%; dimethylsulfoxide, 5%; salicyclic acid, 0.5% resorcinol,0.5%; mutton oil, 3%; alcohol, 3%; white soft paraffin, 66.5%.

A significant therapeutic effect can be obtained by application of thecream (A, B) alone for therapy or dermatitis onto the diseased part;however, a more significant effect could be obtained by concomitant useof drinking of a tea for therapy of dermatitis (atopic tea), describedbelow, and applying of a lotion (atopic lotion) (A, B) for therapy ofdermatitis, described below, all being developed by the applicant, ontothe diseased part. In the following, the 3 times a day applying of theatopic cream (A, B) and the atopic lotion (A, B) and the drinking of 3 gof the atopic tea were respectively carried out at morning, noon andnight.

The respective ingredients and weight ratios in the tea for therapy ofdermatitis (atopic tea): The weights of extract ingredients drawn fromrespective medical herbs per g of a drinkable tea in the form of powdersor granules are: Lightyellow Sophora Root, 0.1 g; Isatis Leaf, 0.1 g;Terminalis Fruit, 0.02 g; Japanese Angelica Root, 0.05 g; Oldenlandiadiffusa, 0.1 g; Smilax Glabra, 0.12 g; Dried Tangerine Peel, 0.05 g;Wild Chrysanthemum Flower, 0.1 g; Corydalis, 0.02 g; Peppermint, 0.01 g;Baikal Skullcap, 0.05 g; Lithospermum, 0.1 g; kudingcha, 0.05 g;Smartweed, 0.1 g; and Licorice, 0.03 g.

The respective ingredients and volume ratios of lotion for therapy ofdermatitis (atopic lotion) A: Lightyellow Sophora Root, 3%; Turmeric,2%; Magnolia Bark, 2%; Moutan Bark, 2%; Isatis Leaf, 1%; Borneo CamphorTree (Dryobalanops aromatica Gaertn. f.), 1%; Amur Cork Tree, 2%;Angelicae Dahuricae Root, 1%; Lemon, 3%; Smartweed, 2%; Licorice, 0.5%;Cnidii Rhizoma, 0.5%; Japanese Angelica Root, 0.5%; salicyclic acid,0.5% resorcinol, 0.5%; alcohol, 30%; water, 48.5%.

The respective ingredients and volume ratios of lotion for therapy ofdermatitis (atopic lotion) B: Lightyellow Sophora Root, 3%; Turmeric,2%; Magnolia Bark, 2%; Moutan Bark, 2%; Isatis Leaf, 1%; Borneo CamphorTree (Dryobalanops aromatica Gaertn. f.), 1%; Amur Cork Tree, 2%;Angelicae Dahuricae Root, 1%; Lemon, 2%; Smartweed, 2%; Licorice, 0.5%;dimethylsulfoxide, 5%; salicyclic acid, 0.5%; resorcinol, 0.5%; alcohol,26%; water, 48.5%.

[Case 1]

Patient

Distinction of sex: Female

Date of birth: Apr. 23, 1994 (Heisei 6)

Age at initial consultation: 7 years old

Initial consultation: Jun. 14, 2001 (Heisei 13)

Medical history: Two years ago, eczema occurred in hands and legs;thereafter, cracked skin occurred. No improvement in symptom wasobserved by use of steroidal agent and others.

Physical examination: Hands and legs are severely keratinized andcracked; dry and rough.

Prescription: External: Application of 3 times a day of the atopic creamA on the diseased part.

Consequence: After 3 weeks, eczema on both hands and legs commenced.

FIG. 1 (A) shows the condition of the hollow of right hand at theinitial consultation; FIG. 1 (B) shows the condition of the hollow ofright hand after 3 weeks of treatment. FIG. 2 (A) shows the condition ofthe sole of left foot at the initial consultation. FIG. 2 (B) shows thecondition of the sole of left foot after 3 weeks of treatment.

[Case 2]

Patient

Distinction of sex: Female

Date of birth: Jul. 9, 1996 (Heisei 8)

Age at initial consultation: 3 years old

Initial consultation: Mar. 29, 1999 (Heisei 11)

Medical history: Onset was from 1 year after birth.

Physical examination: Particularly severe dermatitis on a partcontacting with a diaper; the part is reddish and swollen, dry andrough.

Prescription: External: Application of 3 times a day of the atopic creamB on the diseased part.

Consequence: Effect was gradually appeared from 1 month; now, after 2months, redness and swelling was improved. After passage of 2 months,drinking of atopic tea was continued.

FIG. 3 (A) shows the condition of the lower abdominal region at theinitial consultation. FIG. 3 (B) shows the condition of the lowerabdominal region after treatment of 2 months.

[Case 3]

Patient

Distinction of sex: Female

Date of birth: Oct. 30, 1986 (Showa 61)

Age at initial consultation: 12 years old

Inditial consultation: Aug. 31, 1998 (Heisei 10)

Medical history: Onset of atopy was after birth and accompanied byasthma; Gradual aggravation from elementally school girl. No improvementwas observed after use of steroidal agent.

Physical examination: Face is reddish and swollen with significantexfoliation of skin; skin of total body is rough with eczema and burn.Lichenification was found locally and there is a strong itching.

Prescription: External: Aplication of 3 times a day of atopic cream Aand atopic lotion A on the diseased part.

Consequence: After 3 months, the symptom was significantly improved.Afterwards, only the drinking of the atopic tea was continued, and thecourse is in good order.

FIG. 4 (A) shows the condition of the face at the initial consultation;FIG. 4 (B) shows the condition of the face when 3 months were passedafter starting the treatment.

[Case 4]

Patient

Distinction of sex: Female

Date of birth: Jan. 7, 1975 (Showa 50)

Age at initial consultation: 23 years old

Initial consultation: Mar. 8, 2001 (Heisei 13)

Medical history: Onset of atopy was at about elementary school girl age.No improvement was observed on use of steroidal agent. Two years ago,aggravation was found after delivery; exanthema and flare were found onall of face, extremities and trunk.

Physical examination: Exanthema, flare, regional erosion, strong itchand burn were found on face.

Skin of both hands is reddish, tumefacient and cracked. Lichenificationwas found locally.

Prescription: External: Application of 3 times a day of atopic cream Aand atopic lotion A on the diseased part.

Internal: Drinking of 3 g per day of the atopic tea.

Consequence: After 3 weeks, eczema, flare, erosion, cracking and so onwere almost completely cured; singificant improvement of itching wasfound.

FIG. 5 (A) shows the condition of the face at the initial consultation;FIG. 5 (B) shows the condition of the face on day 13 after thetreatment. FIG. 6 (A) shows the condition of the backside of right handat the initial consultation; FIG. 6 (B) shows the condition of thebackside of right hand on day 20 ater the treatment.

[Case 5]

Patient

Distinction of sex: Male

Date of birth: Mar. 15, 1999 (Heisei 11)

Age at initial consultation: 0 year old (24 days after birth)

Initial consultation: Apr. 8, 1999 (Heisei 11)

Medical history: Onset of eczema was 2 weeks after birth on face as mainpart, head, neck and round, ears, trunk and others. No improvement wasfound after use of commercially available drug.

Physical examination: Exzema, exanthema and swelling on face, head, neckand round; regional pus.

Prescription: External: Application of 3 times a day of atopic cream Band atopic lotion B on the diseased part.

Internal: Drinking of 3 g per day of the atopic tea.

Consequence: After 2 weeks, the skin manifestation was significantlyimproved, and 2 months later, the symptoms were settled and thetreatment was discontinued.

FIG. 7 (A) shows the condition of the face at the initial consultation;FIG. 7 (B) shows the condition of the face after 2 months.

[Case 6]

Patient

Distinction of sex: Male

Date of birth: Jan. 21, 1976 (Showa 51)

Age at initial consultation: 22 years old

Initial consultation: Dec. 11, 1998 (Heisei 10)

Medical history: Onset of atopy was at middle school boy age; gradualaggravation occurred during university student age; no improvement wasobserved by use of steroidal agent.

Physical examination: Flare and eczema on face and head; dry and rough.Severe eczema on both hands; strong erosion, pus, itching and burn.

Prescription: External: Application of 3 times a day of atopic cream Band atopic lotion B on the diseased part.

Internal: Drinking of 3 g per day of the atopic tea.

Consequence: After 3 weeks, eczema on both hands was almost completelycured.

Improving effect was observed in symptoms on face and head.

FIG. 8 (A) shows the condition of the fingers of right hand at theinitial consultation; FIG. 8 (B) shows the condition of the fingers ofright hand after 3 weeks.

[Case 7]

Patient

Distinction of sex: Female

Date of birth: Jun. 12, 1984 (Showa 59)

Age at initial consultation: 14 years old

Initial consultation: Dec. 20, 1998 (Heisei 10)

Medical history: Onset of atopy was at infancy. One year ago,aggravation occurred and onset was found on all of face, trunk andextremities; erosion and pus were found. Particularly, exanthema ongluteal region and both lower limb was severe and there is a strongitching and burn.

Crack on the sole of right foot was found.

Prescription: External: Application of 3 times a day of atopic cream Band atopic lotion A on the diseased part.

Internal: Drinking of 3 g per day or the atomic tea.

Consequence: After 2 weeks, improvement of symptoms was found. Crack onthe sole of right foot was completely cured. Afterwards, only thedrinking of the cream was continued, and the course is in good order.

FIG. 9 (A) shows the condition of the sole of right foot at the initialconsultation; FIG. 9 (B) shows the condition of the sole of right footafter 2 weeks.

[Case 8]

Patient

Distinction of sex: Male

Date of birth: Dec. 11, 1980 (Showa 55)

Age at initial consultation: 20 years old

Initial consultation: Apr. 1, 1999 (Heisei 11)

Medical history: Onset of atopy was after birth; steroid therapy wasattempted at elementary to middle school boy age but no effect was foundand the therapy was discontinued. Thereafter, antihistaminic agent alonewas taken.

Physical examination: exanthema, dark redness and pigmentation on face;red swelling on neck, trunk and joints in extremities; many exfoliation;lichenification was found locally; itching is strong.

Prescription: External: Application of 3 times a day of atopic cream Aand atopic lotion B on the diseased part.

Internal: Drinking of 3 g per day of the atopic tea.

Consequence: After 2 months, eczema, dark redness and pigmentation onface were almost completely cured.

Exzema on trunk and extremities were significantly improved and thecourse afterwards is in good order.

FIG. 10 (A) shows the condition of the face at the initial consultation;FIG. 10 (B) shows the condition of the face after 2 months.

As shown in CASE 1 and CASE 2, an excellent therapeutic effect can beobtained by only applying of the cream for therapy of dermatitis; a moresignificant therapeutic effects can be obtained by concurrently occurredeffect of the improvement of physical constitution from the inside ofthe body and direct therapeutic effect to the diseased part when anatopic tea is taken or an atopic cream (A, B) is applied concomitantlyin the initial stage of the therapy or during the total period of thetherapy.

Besides, although description in the above examples relates to caseswherein the accelerating agent for skin permeation consisting of CnidiiRhizoma plus Japanese Angelicae Root was used in the cream A for therapyof dermatitis and cases wherein the accelerating agent for skinpermeation consisting of dimethylsulfoxide was used in the cream B fortherapy of dermatitis, similarly significant effects could be obtainedin cases wherein the accelerating agent for skin permeation consistingof Cnidii Rhizoma or Japanese Angelicae Root alone was used, caseswherein the accelerating agent for skin permeation consisting of CnidiiRhizoma plus dimethylsulfoxide was used, cases wherein the acceleratingagent for skin permeation consisting of Japanese Angelicae Root plusdimethylsulfoxide was used, and cases wherein the accelerating agent forskin permeation consisting of Cnidii Rhizoma plus Japanese AngelicaeRoot plus dimethylsulfoxide was used.

1. A cream for therapy of dermatitis characterized in that it contains extracts drawn from one, two or more plants selected from the group consisting of Lightyellow Sophora Root, Turmeric, Magnolia Bark, Moutan Bark, Isatis Leaf, and Borneo Camphor Tree (Dryobalanops aromatica Gaertn. f.).
 2. The cream for therapy of dermatitis described in claim 1 characterized in that an auxiliary agent is added to the said extracts drawn from plants.
 3. The cream for therapy of dermatitis described in claim 1 characterized in that said auxiliary agent includes an auxiliary extract drawn from a plant, accelerator for skin permeation, accelerator for keratinization, mutton oil, alcohol and white soft paraffin.
 4. The cream for therapy of dermatitis described in claim 3 characterized in that said auxiliary extract drawn from a plant contains extracts drawn from one, two or more selected from the group of Baikal Skullcap, Amur Cork Tree, Angelicae Dahuricae Root, Lemon, Smartweed and Licorice.
 5. The cream for therapy of dermatitis described in claim 3 characterized in that said accelerating agent for skin permeation contains one, two or more selected from the group of Cnidii Rhizoma, Japanese Angelicae Root and dimethylsulfoxide.
 6. The cream for therapy of dermatitis described in claim 3 characterized in that said accelerating agent for keratinization contains one or two selected from the group of salicylic acid and resorcinol.
 7. The cream for therapy of dermatitis described in claim 3 characterized in that the ratios of the extracts drawn from plants: accelerating agent for skin permeation: accelerating agent for keratinization in said auxiliary agent are 53 to 89%: 8 to 38%: 6 to 10%.
 8. The cream for therapy of dermatitis described in claim 2 characterized in that said auxiliary agent includes an auxiliary extract drawn from a plant, accelerator for skin permeation, accelerator for keratinization, mutton oil, alcohol and white soft paraffin.
 9. A cream for therapy of dermatitis characterized in that the volume ratios of respective ingredients are Lightyellow Sophora Root, 2.7 to 3.3%; Turmeric, 1.8 to 2.2%; Magnolia Bark, 1.8 to 2.2%; Moutan Bark, 1.8 to 2.2%; Isatis Leaf, 0.9 to 1.1%; Borneo Camphor Tree (Dryobalanops aromatica Gaertn. f.), 0.9 to 1.1%; Baikal Skullcap, 1.8 to 2.2%; Amur Cork Tree, 1.8 to 2.2%; Angelicae Dahuricae Root, 0.9 to 1.1%; Lemon, 0 to 3%; Smartweed, 0 to 1.1%; Licorice, 0 to 0.55%; Cnidii Rhizoma, 0.45 to 1.1%; Japanese Angelica Root, 0 to 0.55%; salicylic acid, 0.45 to 0.55%; resorcinol, 0.45 to 0.55%; mutton oil, 2.7 to 3.3%; alcohol, 2.7 to 3.3%; and white soft paraffin, 63 to 78%.
 10. A cream for therapy of dermatitis characterized in that the volume ratios of respective ingredients are Lightyellow Sophora Root, 3%; Turmeric, 2%; Magnolia Bark, 2%; Moutan Bark, 2%; Isatis Leaf, 1%; Borneo Camphor Tree (Dryobalanops aromatica Gaertn. f.), 1%; Baikal Skullcap, 2%; Amur Cork Tree, 2%; Angelicae Dahuricae Root, 1%; Lemon, 3%; Smartweed, 1%; Licorice, 0.5%; Cnidii Rhizoma, 0.5%; Japanese Angelica Root, 0.5%; salicylic acid, 0.5%; resorcinol, 0.5%; mutton oil, 3%; alcohol, 3%; and white soft paraffin, 70.5%.
 11. A cream for therapy of dermatitis characterized in that the volume ratios of respective ingredients are Lightyellow Sophora Root, 2.7 to 3.3%; Turmeric, 1.8 to 2.2%; Magnolia Bark, 1.8 to 2.2%; Moutan Bark, 1.8 to 2.2%; Isatis Leaf, 0.9 to 1.1%; Borneo Camphor Tree (Dryobalanops aromatica Gaertn. f.), 0.9 to 1.1%; Baikal Skullcap, 1.8 to 2.2%; Amur Cork Tree, 1.8 to 2.2%; Angelicae Dahuricae Root, 0.9 to 1.1%; Lemon, 0 to 3%; Smartweed, 0 to 1.1%; Licorice, 0 to 0.55%; dimethylsulfoxide, 4.5 to 5.5%; salicylic acid, 0.45 to 0.55%; resorcinol, 0.45 to 0.55%; mutton oil, 2.7 to 3.3%; alcohol, 2.7 to 3.3%; and white soft paraffin, 60 to 73%.
 12. A cream for therapy of dermatitis characterized in that the volume ratios of respective ingredients are Lightyellow Sophora Root, 3%; Turmeric, 2%; Magnolia Bark, 2%; Moutan Bark, 2%; Isatis Leaf, 1%; Borneo Camphor Tree (Dryobalanops aromatica Gaertn. f.), 1%; Baikal Skullcap, 2%; Amur Cork Tree, 2%; Angelicae Dahuricae Root, 1%; Lemon, 3%; Smartweed, 1%; Licorice, 0.5%; dimethylsulfoxide, 5%; salicylic acid, 0.5%; resorcinol, 0.5%; mutton oil, 3%; alcohol, 3%; and white soft paraffin, 66.5%. 